Part 2. Genomics
2.8. Expression Profiling
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Smirnov, D. A. and Cheung, V. G. 2005. Microarray CGH. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.8:93.
- Published Online: 15 APR 2005
Comparative genomic hybridization (CGH) is a molecular cytogenetic method for detection of chromosomal abnormalities. Traditionally, normal metaphase chromosomes were used as substrates for CGH analysis. Recent advances in microarray technology and developments in the human genome project allow substitution of metaphase chromosomes with collections of arrayed genomic clones, cDNA clones, or oligonucleotides. When combined with such microarrays, CGH can be used for genome-wide high-resolution characterization of cytogenetic imbalances. This review focuses on recent advances and remaining challenges in manufacturing genomic microarrays and using them for identification of chromosomal abnormalities by microarray CGH.
- comparative genomic hybridization;
- array CGH;
- genomic microarrays;
- genetic diagnostics;
- chromosomal imbalances;