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The promise of gene signatures in cancer diagnosis and prognosis

Part 2. Genomics

2.8. Expression Profiling

Specialist Review

  1. Jimmy C. Sung,
  2. Alice Y. Lee,
  3. Timothy J. Yeatman

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g208205

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Sung, J. C., Lee, A. Y. and Yeatman, T. J. 2005. The promise of gene signatures in cancer diagnosis and prognosis. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.8:96.

Author Information

  1. The H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL, USA

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Gene-expression profiling is a relatively new technology that has promise for developing mathematical models that might be useful in predicting diagnoses and prognoses for a number of different cancer types. While the promise of this approach has not yet been realized, there is accumulating evidence that this approach is feasible. Extensive validation of all molecular classifiers with large independent test sets will be necessary prior to clinical application.

Keywords:

  • microarray;
  • prognosis;
  • diagnosis;
  • gene profiling;
  • gene signature