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Genomic analysis of host pathogen interactions

Part 2. Genomics

2.8. Expression Profiling

Short Specialist Review

  1. Paul Kellam,
  2. Catherine V. Gale

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g208304

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Kellam, P. and Gale, C. V. 2005. Genomic analysis of host pathogen interactions. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.8:99.

Author Information

  1. University College London, London, UK

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Infection of multicellular organisms by microbes occurs throughout, and can shape, the evolutionary history of both the host and the pathogen. Following exposure, transcriptional remodeling of infected cells and cells of the innate and adaptive arms of the immune system results in both disease symptoms and eventually in pathogen clearance. Failure of this integrated system results in host death. More sophisticated microbes are able to dramatically blunt cellular defense mechanisms, and in some cases, reprogram cellular gene networks to allow persistence within the host. This is sometimes a beneficial, symbiotic relationship, but often results in life-long host infection, occasionally with delayed pathogenesis. Transcriptional profiling studies have started to uncover the coordinated host response to microbial encounter that should ultimately produce a greater understanding of microbial pathogenesis.

Keywords:

  • host pathogen interaction;
  • microarrays;
  • remodeling;
  • transcriptome;
  • virus;
  • bacteria