Genomic analysis of host pathogen interactions
Part 2. Genomics
2.8. Expression Profiling
Short Specialist Review
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Kellam, P. and Gale, C. V. 2005. Genomic analysis of host pathogen interactions. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.8:99.
- Published Online: 15 JUL 2005
Infection of multicellular organisms by microbes occurs throughout, and can shape, the evolutionary history of both the host and the pathogen. Following exposure, transcriptional remodeling of infected cells and cells of the innate and adaptive arms of the immune system results in both disease symptoms and eventually in pathogen clearance. Failure of this integrated system results in host death. More sophisticated microbes are able to dramatically blunt cellular defense mechanisms, and in some cases, reprogram cellular gene networks to allow persistence within the host. This is sometimes a beneficial, symbiotic relationship, but often results in life-long host infection, occasionally with delayed pathogenesis. Transcriptional profiling studies have started to uncover the coordinated host response to microbial encounter that should ultimately produce a greater understanding of microbial pathogenesis.
- host pathogen interaction;