Bacterial genome organization: comparative expression profiling, operons, regulons, and beyond
Part 2. Genomics
2.8. Expression Profiling
Short Specialist Review
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Peterson, S. N. 2005. Bacterial genome organization: comparative expression profiling, operons, regulons, and beyond. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.8:98.
- Published Online: 15 JUL 2005
The sequencing of complete microbial genomes has provided a molecular basis for the diversity of bacterial species. Bacterial gene expression in response to environmental stimuli may be equally diverse and raises the question as to how well what we learn about gene expression in one species translates to another. A problem common to all scientists performing global gene expression lies in determining the significance of gene expression changes as they relate to the functional requirements of the encoded proteins in the biological process under investigation. Four recent studies are presented that highlight some of the issues that confound direct interpretation of gene expression data, including operon structure, functional redundancy of proteins, and the occurrence of nonorthologous genes in bacteria. The concept of comparative expression profiling (CEP) is introduced and discussed in the context of the experimental results observed.
- comparative expression profiling;
- DNA microarrays;
- gene expression;
- genome organization;
- non-orthologous genes