Standard Article

FT-ICR

Part 3. Proteomics

3.1. Core Methodologies

Specialist Review

  1. Mark P. Barrow,
  2. William I. Burkitt,
  3. Peter J. Derrick

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g301203

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Barrow, M. P., Burkitt, W. I. and Derrick, P. J. 2005. FT-ICR. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.1:5.

Author Information

  1. University of Warwick, Coventry, UK

Publication History

  1. Published Online: 15 JAN 2005

Abstract

Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry has become an increasingly significant technique within recent years. The inherently ultrahigh resolution and mass accuracy allow unequivocal assignments of elemental composition to be made for biomolecules. Structural elucidation can be conducted through tandem mass spectrometry experiments. With the advent of electrospray ionization (ESI), FT-ICR mass spectrometry has become a powerful tool for the investigation of biological macromolecules, including aspects of noncovalent interactions.

Keywords:

  • Fourier transform ion cyclotron resonance;
  • mass spectrometry