Standard Article

Orbitrap mass analyzer

Part 3. Proteomics

3.1. Core Methodologies

Specialist Review

  1. Alexander Makarov1,
  2. Michaela Scigelova2

Published Online: 15 DEC 2006

DOI: 10.1002/047001153X.g301222

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Makarov, A. and Scigelova, M. 2006. Orbitrap mass analyzer. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.1.

Author Information

  1. 1

    Thermo Electron, Bremen, Germany

  2. 2

    Thermo Electron, Hemel Hempstead, UK

Publication History

  1. Published Online: 15 DEC 2006

Abstract

The orbitrap mass analyzer is fast becoming a unique and powerful addition to the scientific toolbox for probing biological systems and increasing selectivity and confidence of routine analyses. The key attributes of this analyzer are accurate mass and high resolution similar to those achievable with FTICR instrumentation. The principles of operation underlying these capabilities are discussed, and a concise overview of application areas that have already benefited from the introduction of this technology is provided.

Keywords:

  • orbitrap mass analyzer;
  • mass spectrometry;
  • FT;
  • hybrid mass spectrometer;
  • proteomics