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Nano-MALDI and Nano-ESI MS

Part 3. Proteomics

3.1. Core Methodologies

Short Specialist Review

  1. Gyorgy Marko-Varga,
  2. Johan Nilsson,
  3. Thomas Laurell

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g301311

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Marko-Varga, G., Nilsson, J. and Laurell, T. 2005. Nano-MALDI and Nano-ESI MS. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.1:11.

Author Information

  1. Lund University, Lund, Sweden

Publication History

  1. Published Online: 15 APR 2005

Abstract

Chip-based techniques are impacting bioanalytical methodology at an increasing rate. The major reason for this is found in the benefits that may be gained by the scaling laws that govern the physics and chemistry, determining the performance of these systems. Mass spectrometry as an analytical tool has dramatically impacted and is still revolutionizing the way that bioanalytical research is executed. It can therefore be anticipated that the oncoming decade will demonstrate remarkable performance improvements in the area. Microscaled technologies have already proved to be an important route in advancing throughput, reducing sample volume requirements, and increasing readout sensitivity in mass spectrometry. In this respect, the current chapter overviews some of the strategies pursued to gain system performance as the dimensions were reduced when processing and delivering biological sample for MS readout.

Keywords:

  • miniaturization;
  • chip;
  • MALDI;
  • ESI;
  • nanoproteomics