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Quadrupole ion traps and a new era of evolution

Part 3. Proteomics

3.1. Core Methodologies

Short Specialist Review

  1. Jae C. Schwartz

Published Online: 15 OCT 2004

DOI: 10.1002/047001153X.g301314

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Schwartz, J. C. 2004. Quadrupole ion traps and a new era of evolution. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.1:9.

Author Information

  1. Thermo Electron Corporation, San Jose, CA, USA

Publication History

  1. Published Online: 15 OCT 2004

Abstract

Quadrupole ion traps have evolved from an interesting tool used by a handful of physicists to study fundamental properties of trapped ions to a uniquely powerful mass spectrometer widely used for determining the structure and sequence of biological and nonbiological samples. As a mass spectrometer, the quadrupole ion traps' unique features include the ability to perform rapid and highly efficient MSn analysis for detailed structural analysis while maintaining high duty cycles even for full scan mass analysis. This makes quadrupole ion traps one of the most sensitive types of mass spectrometers for qualitative analysis and is the foundation for their success. Quadrupole ion trap technology is now entering a new era based on the evolution of the traditional three-dimensional ion trap into a two-dimensional linear ion trap. With this evolution comes a significant leap in the overall fundamental performance characteristics and also the promise for further future capabilities.

Keywords:

  • quadrupole ion trap;
  • linear trap;
  • mass spectrometer;
  • instrumentation;
  • peptide sequencing;
  • protein identification;
  • data-dependent analysis