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Quadrupole mass analyzers: theoretical and practical considerations

Part 3. Proteomics

3.1. Core Methodologies

Short Specialist Review

  1. Frank A. Kero1,
  2. Randall E. Pedder2,
  3. Richard A. Yost1

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g301319

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Kero, F. A., Pedder, R. E. and Yost, R. A. 2005. Quadrupole mass analyzers: theoretical and practical considerations. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.1:8.

Author Information

  1. 1

    University of Florida, Gainesville, FL, USA

  2. 2

    Ardara Technologies LP, Monroeville, PA, USA

Publication History

  1. Published Online: 15 NOV 2005

Abstract

Mass spectrometry is perhaps the key core methodology for proteomics, and the quadrupole mass analyzer is currently the most widely used mass analyzer in proteomic applications of mass spectrometry. The theory of quadrupole mass analyzers (and of the related quadrupole and multipole devices used to confine and transmit beams of ions into and between mass analyzers) can lend valuable insight into practical considerations for effective use of mass spectrometry.

Keywords:

  • quadrupole;
  • mass spectrometer;
  • mass filter;
  • multipole;
  • instrumentation;
  • MS/MS;
  • LC/MS;
  • LC/MS/MS