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Protein interactions in cellular signaling

Part 3. Proteomics

3.3. Mapping of Biochemical Networks

Introductory Review

  1. Tony Pawson

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g303113

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Pawson, T. 2005. Protein interactions in cellular signaling. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.3:34.

Author Information

  1. Samuel Lunenfeld Research Institute, Toronto, ON, Canada

Publication History

  1. Published Online: 15 APR 2005

Abstract

Protein–protein interactions provide a fundamental mechanism through which cellular regulatory systems are organized, and specificity is imposed during signal transduction. Furthermore, the association of proteins into larger complexes supports the formation of more extended biochemical pathways and interaction networks that link and integrate different aspects of cellular behavior. The molecular principles that underlie protein–protein interactions also explain the ability of proteins to recognize specific phospholipids, nucleic acids, and second messengers, and, therefore, define a general theme in proteomics and cell biology.

Keywords:

  • protein–protein interactions;
  • phosphorylation;
  • domains;
  • signal transduction