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The C. elegans interactome project

Part 3. Proteomics

3.3. Mapping of Biochemical Networks

Specialist Review

  1. David E. Hill,
  2. Michael E. Cusick,
  3. Marc Vidal

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g303210

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Hill, D. E., Cusick, M. E. and Vidal, M. 2005. The C. elegans interactome project. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.3:38.

Author Information

  1. Dana-Farber Cancer Institute, Harvard Medical School, Center for Cancer Systems Biology, Boston, MA, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

The long-term goal of the research described in this chapter is to understand how macromolecular networks control animal development and how changes in such networks can lead to human diseases. Recently released protein–protein interaction or “interactome” maps for multicellular organisms have helped us to start imagining how complex cellular networks are organized.

Keywords:

  • ORFeome;
  • C. elegans;
  • functional genomics;
  • systems biology;
  • yeast two-hybrid;
  • networks;
  • interactome maps;
  • phenome;
  • transcriptome;
  • protein–protein interaction;
  • integration