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Human signaling pathways analyzed by protein interaction mapping

Part 3. Proteomics

3.3. Mapping of Biochemical Networks

Short Specialist Review

  1. Frédéric Colland1,
  2. Pierre Legrain2

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g303303

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Colland, F. and Legrain, P. 2005. Human signaling pathways analyzed by protein interaction mapping. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.3:40.

Author Information

  1. 1

    Hybrigenics SA, Paris, France

  2. 2

    CEA Saclay, Gif-sur-Yvette, France

Publication History

  1. Published Online: 15 JAN 2005

Abstract

Combining protein–protein interaction mapping with cellular assays performed for functional validation provides biological support to large-scale protein interaction datasets. This strategy was recently developed for specific signal transduction pathways and generates useful biological knowledge.

Keywords:

  • protein–protein interaction;
  • yeast two-hybrid system;
  • TGFβ;
  • TNFα;
  • signaling pathway;
  • functional validation