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Topology of protein interaction networks and cell physiology

Part 3. Proteomics

3.3. Mapping of Biochemical Networks

Short Specialist Review

  1. Marie-Claude Marsolier-Kergoat

Published Online: 15 APR 2006

DOI: 10.1002/047001153X.g303319

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Marsolier-Kergoat, M.-C. 2006. Topology of protein interaction networks and cell physiology. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.3.

Author Information

  1. Service de Biochimie et de Génétique Moléculaire, CEA/Saclay, Gif-sur-Yvette, France

Publication History

  1. Published Online: 15 APR 2006

Abstract

The first descriptions of large protein interaction networks have revealed unexpected topological properties that have been linked to various aspects of cell physiology. In this paper are reviewed the proposed connections between local or global features of protein networks and biological parameters like protein essentiality or mutational robustness.

Keywords:

  • network;
  • protein;
  • interaction;
  • topology;
  • mutational robustness;
  • essentiality