Posttranslational modification of proteins
Part 3. Proteomics
3.5. Proteome Diversity
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Larsen, M. R. and Jensen, O. N. 2005. Posttranslational modification of proteins. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.5:61.
- Published Online: 15 APR 2005
The elucidation of posttranslational modification of proteins is a prerequisite for understanding the molecular details of living organisms, from bacteria to plants and mammals. Protein phosphorylation plays a key role in cell signaling during cellular development, growth, and differentiation. Protein processing is required for the maturation of proteins and for activation and turnover. The ability to detect and monitor posttranslational modifications and processing of proteins by mass spectrometry and other analytical methods is already providing exciting insights into key regulatory events in cells and organisms, in health, and in disease.
- mass spectrometry;
- protein processing;
- phosphopeptide sequencing;
- affinity enrichment