Protein glycosylation and renal cancer
Part 3. Proteomics
3.5. Proteome Diversity
Published Online: 15 OCT 2006
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Ferguson, R. E., Vasudev, N. S., Selby, P. J. and Banks, R. E. 2006. Protein glycosylation and renal cancer. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 OCT 2006
Glycosylation is the most complex and common posttranslational modification. The development of cancer is associated with profound alterations in cellular glycosylation. Glycosylated proteins (glycoproteins) coat all eukaryotic cells and play pivotal roles in many aspects of tumor progression, including proliferation, invasion, metastasis, and angiogenesis. Recent technological advances in glycobiology have enabled the identification of glycan structures that are associated with particular disease states, thereby facilitating the exploitation of such changes in glycan-based diagnostics and therapeutics. This review outlines how glycosylation alters with cancer, how such changes may be targeted for diagnostic and therapeutic means, and describes what is known currently about altered glycosylation in renal cancer.
- post-translational modification;