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O-glycan processing

Part 3. Proteomics

3.5. Proteome Diversity

Short Specialist Review

  1. Anthony P. Corfield

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g305303

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Corfield, A. P. 2005. O-glycan processing. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.5:70.

Author Information

  1. University of Bristol, Bristol, UK

Publication History

  1. Published Online: 15 APR 2005

Abstract

The Ser (Thr)-GalNAc class of O-glycan chains found in glycoproteins are formed through a series of sequential transfer reactions without participation of lipid intermediates. The products of these pathways generate predictable structures found on a wide variety of proteins. The formation of truncated, incomplete glycans arises through regulation of the expression of the transferases on these pathways or through the action of glycosidases and other catabolic enzymes. Examples of O-glycan involvement with the processing of glycoproteins is described for protein synthesis and expression, proteolytic processing, subcellular localization of proteins, developmental expression of proteins, and immune cell expression and response.

Keywords:

  • O-glycan;
  • O-glycan biosynthesis;
  • O-glycan processing;
  • protein processing;
  • oligosaccharide;
  • mucin type;
  • glycosyltransferase