Part 3. Proteomics
3.5. Proteome Diversity
Short Specialist Review
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Corfield, A. P. 2005. O-glycan processing. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 APR 2005
The Ser (Thr)-GalNAc class of O-glycan chains found in glycoproteins are formed through a series of sequential transfer reactions without participation of lipid intermediates. The products of these pathways generate predictable structures found on a wide variety of proteins. The formation of truncated, incomplete glycans arises through regulation of the expression of the transferases on these pathways or through the action of glycosidases and other catabolic enzymes. Examples of O-glycan involvement with the processing of glycoproteins is described for protein synthesis and expression, proteolytic processing, subcellular localization of proteins, developmental expression of proteins, and immune cell expression and response.
- O-glycan biosynthesis;
- O-glycan processing;
- protein processing;
- mucin type;