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O-Mannosylation

Part 3. Proteomics

3.5. Proteome Diversity

Short Specialist Review

  1. Tamao Endo

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g305308

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Endo, T. 2005. O-Mannosylation. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.5:71.

Author Information

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

Publication History

  1. Published Online: 15 JAN 2005

Abstract

Mammalian cells produce many glycoproteins, that is, proteins with covalently attached sugar chains. The major glycans of glycoproteins can be classified into two groups, N-glycan and O-glycan, according to their glycan-peptide linkage regions. Developments in glycobiology have revealed a new type of glycosidic linkage to the peptide portion, the O-mannosyl linkage. This linkage used to be considered specific to yeast but has recently been found in mammals. Recently, O-mannosylation has been shown to be important in muscle and brain development. This chapter describes the structure, biosynthesis, and biology of O-mannosylation.

Keywords:

  • glycobiology;
  • O-mannosylation;
  • muscular dystrophy;
  • dystroglycan;
  • glycosyltransferase