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O-linked N-acetylglucosamine (O-GlcNAc)

Part 3. Proteomics

3.5. Proteome Diversity

Short Specialist Review

  1. Stephen A. Whelan,
  2. Gerald W. Hart

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g305313

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Whelan, S. A. and Hart, G. W. 2005. O-linked N-acetylglucosamine (O-GlcNAc). Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.5:72.

Author Information

  1. The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and dynamic posttranslational modification that occurs on serine and threonine residues in functionally diverse nucleocytoplasmic proteins in all metazoans. O-GlcNAc has been characterized to have functional roles in a number of disease states, as a nutrient sensor, in protein–protein interactions, and protein degradation. The regulation of these cellular functions, as well as many other potential functions, is studied through the use and development of proteomic techniques. Identifying O-GlcNAc sites, in conjunction with other posttranslational modifications, will continue to play an essential role toward elucidating the complex regulation of proteins and the control on the cellular state.

Keywords:

  • O-linked β-N-acetylglucosamine;
  • O-GlcNAc;
  • OGT;
  • O-GlcNAcase;
  • hexosamine biosynthesis;
  • UDP-GlcNAc;
  • proteomics;
  • Michael addition;
  • mass spectrometry