O-linked N-acetylglucosamine (O-GlcNAc)
Part 3. Proteomics
3.5. Proteome Diversity
Short Specialist Review
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Whelan, S. A. and Hart, G. W. 2005. O-linked N-acetylglucosamine (O-GlcNAc). Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 APR 2005
O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and dynamic posttranslational modification that occurs on serine and threonine residues in functionally diverse nucleocytoplasmic proteins in all metazoans. O-GlcNAc has been characterized to have functional roles in a number of disease states, as a nutrient sensor, in protein–protein interactions, and protein degradation. The regulation of these cellular functions, as well as many other potential functions, is studied through the use and development of proteomic techniques. Identifying O-GlcNAc sites, in conjunction with other posttranslational modifications, will continue to play an essential role toward elucidating the complex regulation of proteins and the control on the cellular state.
- O-linked β-N-acetylglucosamine;
- hexosamine biosynthesis;
- Michael addition;
- mass spectrometry