Classification of proteins into families
Part 3. Proteomics
3.6. Proteome Families
Published Online: 15 JAN 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Mulder, N. J. and Apweiler, R. 2005. Classification of proteins into families. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.6:78.
- Published Online: 15 JAN 2005
Functional annotation of proteins is vital for a thorough understanding of genomic systems, diseases, and pathogenesis. With the genome era in full swing, thousands of new sequences from genome sequencing projects are available, but they cannot be manually annotated. Reliable methods for automatic functional classification of proteins are being developed. The most useful tools use various methods for identifying motifs or domains found in previously characterized protein families. Protein families can be classified using two main approaches: sequence clustering and protein signatures. Once members of a protein family are discovered, inference of functional annotation to all members is possible. This chapter reviews the existing methods using these approaches and the major databases in the public domain that implement the methods.
- protein family;
- functional classification;
- hidden Markov model;
- regular expression;