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Metalloproteins

Part 3. Proteomics

3.6. Proteome Families

Specialist Review

  1. Kirill Degtyarenko

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g306204

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Degtyarenko, K. 2005. Metalloproteins. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.6:79.

Author Information

  1. European Bioinformatics Institute, Cambridge, UK

Publication History

  1. Published Online: 15 APR 2005

Abstract

Blood is red in vertebrates and blue in molluscs thanks to protein–metal complexes. Metalloproteins are involved in all fundamental biochemical processes including respiration, oxygenic photosynthesis, regulation of transcription and translation, nitrogen fixation, and metabolism of xenobiotics. Metalloenzymes were the first biological catalysts on Earth. Later, when the composition of the Earth's atmosphere changed dramatically due to photosynthesis, the metalloproteins evolved to counter the toxic effects of oxygen and harness it for new physiological functions. Currently, over one-half of all proteins are estimated to bind metals. This article introduces but a small number of metalloprotein families, with emphasis on oxidoreductases, electron-transfer proteins, and photosynthetic complexes.

Keywords:

  • bioinorganic chemistry;
  • cytochromes;
  • metallochaperones;
  • metalloenzymes;
  • electron transfer;
  • oxidoreductases;
  • photosynthesis