Transporter protein families
Part 3. Proteomics
3.6. Proteome Families
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Ren, Q. and Paulsen, I. T. 2005. Transporter protein families. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.6:81.
- Published Online: 15 APR 2005
Membrane transporters play important roles in many fundamental processes and cellular functions of both prokaryotes and eukaryotes. System approaches have been adopted to the classification of transporter families (TCDB) based on mode of transport and energy-coupling mechanism, molecular phylogeny, and substrate specificity, as well as the whole-genome transporter analyses (TransportDB). The advantage of the incorporation of phylogeny into the classification system and the importance of a phylogenetic approach are underlined by the fact that phylogeny provides reliable guide to the structure, function, and mechanism of transporter proteins, as shown in the example of the phylogenetic study of human ABC transporter.