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Transporter protein families

Part 3. Proteomics

3.6. Proteome Families

Specialist Review

  1. Qinghu Ren,
  2. Ian T. Paulsen

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g306217

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Ren, Q. and Paulsen, I. T. 2005. Transporter protein families. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.6:81.

Author Information

  1. The Institute for Genomic Research, Rockville, MD, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

Membrane transporters play important roles in many fundamental processes and cellular functions of both prokaryotes and eukaryotes. System approaches have been adopted to the classification of transporter families (TCDB) based on mode of transport and energy-coupling mechanism, molecular phylogeny, and substrate specificity, as well as the whole-genome transporter analyses (TransportDB). The advantage of the incorporation of phylogeny into the classification system and the importance of a phylogenetic approach are underlined by the fact that phylogeny provides reliable guide to the structure, function, and mechanism of transporter proteins, as shown in the example of the phylogenetic study of human ABC transporter.

Keywords:

  • transporter;
  • families;
  • classification;
  • TCDB;
  • TransportDB;
  • phylogeny