Standard Article

InterPro

Part 3. Proteomics

3.6. Proteome Families

Short Specialist Review

  1. Nicola J. Mulder

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g306310

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Mulder, N. J. 2005. InterPro. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.6:83.

Author Information

  1. European Bioinformatics Institute, Cambridge, UK

Publication History

  1. Published Online: 15 APR 2005

Abstract

InterPro is an integrated resource for protein families, domains, and active sites. The resource provides an invaluable means for automatic classification of protein sequences into families or domains with a view to providing functional annotation for the proteins. It constitutes an amalgamation of the major protein signature databases: PROSITE, PRINTS, Pfam, ProDom, SMART, TIGRFAMs, PIR SuperFamily, and SUPERFAMILY into a unified database where similarities and differences between the signatures from each of these databases are rationalized for ease of use. All signatures representing the same family or domain are collated into unique InterPro entries, with annotation and a list of the proteins in UniProt that these signatures match. New sequences not available in UniProt can be run through all signatures in InterPro using the InterProScan software. InterPro is useful for large-scale classification of whole genomes, as well as for functional annotation of individual protein sequences.

Keywords:

  • InterPro;
  • protein family;
  • domain;
  • automatic annotation;
  • domain composition;
  • InterProScan;
  • functional classification