Part 3. Proteomics
3.6. Proteome Families
Short Specialist Review
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Mulder, N. J. 2005. InterPro. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.6:83.
- Published Online: 15 APR 2005
InterPro is an integrated resource for protein families, domains, and active sites. The resource provides an invaluable means for automatic classification of protein sequences into families or domains with a view to providing functional annotation for the proteins. It constitutes an amalgamation of the major protein signature databases: PROSITE, PRINTS, Pfam, ProDom, SMART, TIGRFAMs, PIR SuperFamily, and SUPERFAMILY into a unified database where similarities and differences between the signatures from each of these databases are rationalized for ease of use. All signatures representing the same family or domain are collated into unique InterPro entries, with annotation and a list of the proteins in UniProt that these signatures match. New sequences not available in UniProt can be run through all signatures in InterPro using the InterProScan software. InterPro is useful for large-scale classification of whole genomes, as well as for functional annotation of individual protein sequences.
- protein family;
- automatic annotation;
- domain composition;
- functional classification