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Fundamentals of protein structure and function

Part 3. Proteomics

3.7. Structural Proteomics

Specialist Review

  1. James R. Bradford,
  2. Jennifer A. Siepen,
  3. David R. Westhead

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g307214

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Bradford, J. R., Siepen, J. A. and Westhead, D. R. 2005. Fundamentals of protein structure and function. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.7:96.

Author Information

  1. University of Leeds, Leeds, UK

Publication History

  1. Published Online: 15 JAN 2005

Abstract

This chapter describes the steps involved in the formation of three-dimensional structure from amino acid sequence. Proteins have adapted their three-dimensional structures to carry out metabolic and regulatory processes such as enzyme catalysis, molecular transport, signaling, the immune response, and gene expression. To understand the relationship between a protein's structure and function fully, knowledge of that protein's evolutionary history and its interactions is essential. Therefore, we describe the mechanisms by which proteins have evolved. We also describe how molecular recognition drives protein interactions and the types of interaction that take place.

Keywords:

  • amino acids;
  • protein structure;
  • function;
  • evolution;
  • interactions;
  • molecular recognition