Part 3. Proteomics
3.7. Structural Proteomics
Basic Techniques and Approaches
Published Online: 15 JAN 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Firbank, S. 2005. X-ray crystallography. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.7:104.
- Published Online: 15 JAN 2005
Since the late 1950s, X-ray crystallography has been used to determine the structure of proteins with known functions. With the dawn of proteomics, protein-structure determination is now being carried out in order to shed light upon proteins of unknown function, with the hope that knowledge of the structure itself will allow, or at least assist in, the identification of possible protein action. This article describes the stages of protein-structure determination by X-ray crystallography, the basic requirements and considerations at each step, and how crystallography can be applied and is being adapted to benefit the structural-genomics community.
- structure determination;
- model building;
- X-ray diffraction