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Metabolic dynamics in cells viewed as multilayered, distributed, mass-energy-information networks

Part 3. Proteomics

3.8. Systems Biology

Specialist Review

  1. Miguel A. Aon,
  2. Sonia Cortassa

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g308206

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Aon, M. A. and Cortassa, S. 2005. Metabolic dynamics in cells viewed as multilayered, distributed, mass-energy-information networks. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.8:113.

Author Information

  1. The Johns Hopkins University, Baltimore, MD, USA

Publication History

  1. Published Online: 15 NOV 2005

Abstract

The role of mathematical models in integrating available information on metabolic networks is highlighted. General modeling and other quantitative methodologies currently available are critically reviewed and the potential contributions of proteomics complemented by theoretical concepts derived from these modeling frameworks are assessed. The multilayered, distributed, view of cells increases the necessity of a more fundamental understanding of the dynamics of complex reaction networks as well as cytoplasmic organization, on cell physiology. The future of mathematical modeling will be largely determined by the trade-off between completeness and understandability.

Keywords:

  • mathematical models;
  • metabolic flux and control analysis;
  • signaling;
  • proteomics;
  • cytoplasmic organization;
  • pathophysiology;
  • robustness;
  • critical behavior