Standard Article

Systems biology of the heart

Part 3. Proteomics

3.8. Systems Biology

Specialist Review

  1. Denis Noble

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g308211

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Noble, D. 2005. Systems biology of the heart. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.8:115.

Author Information

  1. University Laboratory of Physiology, Oxford, UK

Publication History

  1. Published Online: 15 APR 2005

Abstract

Models of the heart have been developed since 1960, starting with the discovery and modeling of potassium channels. The first models of calcium balance were made in the 1980s and have now reached a high degree of physiological detail. During the 1990s, these cell models have been incorporated into anatomically detailed tissue and organ models. Systems biology of the heart is now well developed and is proving increasingly useful in unraveling complicated physiological functions and in understanding disease states.

Keywords:

  • heart models;
  • disease models;
  • cardiac genetic mutations;
  • congestive heart failure;
  • cardiac ischemia;
  • calcium balance