Integrative modeling of the pancreatic β-cell
Part 3. Proteomics
3.8. Systems Biology
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Sherman, A. and Bertram, R. 2005. Integrative modeling of the pancreatic β-cell. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.8:116.
- Published Online: 15 APR 2005
Pancreatic β-cells secrete insulin, which regulates the concentration of plasma glucose. Dysfunction of this system is a necessary contributing factor to Type II diabetes, and may be sufficient. Insulin secretion is controlled by oscillations of membrane potential, called bursting oscillations, which drive oscillations of cytosolic calcium. We describe the development of mathematical models for this mechanism, beginning with the Chay–Keizer model.
- ion channels;
- endoplasmic reticulum;