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Integrative modeling of the pancreatic β-cell

Part 3. Proteomics

3.8. Systems Biology

Specialist Review

  1. Arthur Sherman1,
  2. Richard Bertram2

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g308213

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Sherman, A. and Bertram, R. 2005. Integrative modeling of the pancreatic β-cell. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.8:116.

Author Information

  1. 1

    National Institutes of Health, Bethesda, MD, USA

  2. 2

    Florida State University, Tallahassee, FL, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

Pancreatic β-cells secrete insulin, which regulates the concentration of plasma glucose. Dysfunction of this system is a necessary contributing factor to Type II diabetes, and may be sufficient. Insulin secretion is controlled by oscillations of membrane potential, called bursting oscillations, which drive oscillations of cytosolic calcium. We describe the development of mathematical models for this mechanism, beginning with the Chay–Keizer model.

Keywords:

  • insulin;
  • diabetes;
  • glucose;
  • calcium;
  • ion channels;
  • endoplasmic reticulum;
  • ATP;
  • mitochondria;
  • metabolism;
  • acetylcholine;
  • IP3