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EGFR network

Part 3. Proteomics

3.8. Systems Biology

Short Specialist Review

  1. Stanislav Y. Shvartsman

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g308314

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Shvartsman, S. Y. 2005. EGFR network. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.8:117.

Author Information

  1. Princeton University, Princeton, NJ, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

The epidermal growth factor receptor (EGFR) network is an evolutionarily conserved regulator of epithelial tissues. At this time, we have a relatively good understanding of the mechanisms by which the EGFR network can control the physiology of a single cell. The current challenge, however, is to understand how this network operates in multicellular systems and tissues. To accomplish this, it will be necessary to integrate information from genetic, biochemical, and cellular studies into predictive, quantitative models.

Keywords:

  • receptor;
  • ligand;
  • computational modeling;
  • embryonic development