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Data collection and analysis in systems biology

Part 3. Proteomics

3.8. Systems Biology

Basic Techniques and Approaches

  1. Trey Ideker

Published Online: 15 OCT 2004

DOI: 10.1002/047001153X.g308407

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Ideker, T. 2004. Data collection and analysis in systems biology. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 3:3.8:118.

Author Information

  1. University of California, San Diego, CA, USA

Publication History

  1. Published Online: 15 OCT 2004

Abstract

Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the global biological response at the gene, protein, and informational pathway level; integrating these data; and ultimately, formulating mathematical models that describe the structure of the system and its response to individual perturbations. The key technologies that enable systems biology are reviewed with a focus on high-throughput measurement technologies and computational modeling approaches for integrating the resulting large-scale data.

Keywords:

  • systems biology;
  • functional genomics;
  • bioinformatics;
  • computer-aided design