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Contig mapping and analysis

Part 4. Bioinformatics

4.1. Genome Assembly and Sequencing

Introductory Review

  1. Asim Siddiqui,
  2. Steven Jones

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g401105

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Siddiqui, A. and Jones, S. 2005. Contig mapping and analysis. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.1:1.

Author Information

  1. British Columbia Cancer Agency, Vancouver, BC, Canada

Publication History

  1. Published Online: 15 APR 2005

Abstract

Physical mapping and the creation of contig maps remains a valuable tool for genomics research. This section describes the methods and techniques used to create contig maps from restriction fragment fingerprint information. It mentions some of the bioinformatics challenges associated with building a high-quality map and points to ongoing research that is attempting to address this problem. This section also illustrates how tiling path clones are chosen from a redundant set of clones.

Keywords:

  • physical mapping;
  • restriction enzyme fingerprints;
  • map contigs;
  • FPC;
  • tiling path;
  • in silico digest;
  • Sulston score