Microbial sequence assembly
Part 4. Bioinformatics
4.1. Genome Assembly and Sequencing
Short Specialist Review
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Weinstock, G. 2005. Microbial sequence assembly. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.1:4.
- Published Online: 15 JUL 2005
Microbial genomes are assembled by the whole-genome shotgun method, where random sequencing is performed to high redundancy and the sequencing reads are assembled en masse. Although the early microbial genome projects relied on a large insert clone tiling path and a clone-by-clone sequencing approach, current assembly software makes it possible to overcome challenges posed by repeated sequences and perform whole-genome shotgun assemblies.
- whole-genome shotgun;
- genome assembly;
- draft genome sequence;
- finished genome sequence