Part 4. Bioinformatics
4.1. Genome Assembly and Sequencing
Short Specialist Review
Published Online: 15 OCT 2004
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Gentles, A. J. and Karlin, S. 2004. Statistical signals. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.1:6.
- Published Online: 15 OCT 2004
Statistical signals play a central role in a wide range of bioinformatics tools and analyses. The basic theory underlying general scoring schemes, particularly maximal aggregate scoring segments, is reviewed briefly. Applications include homology detection using BLAST, alignment algorithms that incorporate global normalization, analysis of distributions of sequence markers (r-scans), and characterization of frequent words and repeat abundances in DNA and protein sequences.
- statistical sequence analysis;
- scoring schemes;
- r-scan analysis;
- frequent words;
- homology searching