Errors in sequence assembly and corrections
Part 4. Bioinformatics
4.1. Genome Assembly and Sequencing
Short Specialist Review
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Tammi, M. T. and Andersson, B. 2005. Errors in sequence assembly and corrections. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 JUL 2005
The shotgun sequencing method is the most economical and easily automated sequencing technique and has thus become the method of choice. Computer software is used to put the pieces together very much like a jigsaw puzzle, but they can usually only produce a good estimate of a correct assembly, and extensive manual finishing is needed to generate the final sequence.
- shotgun sequencing;
- sequencing errors;