Genome maps and their use in sequence assembly
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Dear, P. H. 2005. Genome maps and their use in sequence assembly. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 APR 2005
Genome maps give the location of defined sequence features in the genome and serve as a framework around which to assemble the complete genome sequence. Without them, the complete assembly of complex genomes purely from the shotgun sequence data is effectively impossible. Here, I summarize the principle methods that are used to make detailed genome maps and the ways in which mapping and sequencing are integrated to produce finished genome sequences.
Keywords: genome mapping; genome sequencing; sequence assembly; physical mapping; optical mapping; radiation hybrid; HAPPY mapping; shotgun sequencing