Standard Article

Searching for genes and biologically related signals in DNA sequences

Part 4. Bioinformatics

4.2. Gene Finding and Gene Structure

Specialist Review

  1. Mihaela Pertea

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g402216

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Pertea, M. 2005. Searching for genes and biologically related signals in DNA sequences. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.2:16.

Author Information

  1. The Institute for Genomic Research, Rockville, MD, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

A key component of the most successful gene-finding algorithms is the ability to recognize the DNA and RNA sequence patterns that characterize the biological signals that are critical for transcription, splicing, and translation. This chapter discusses some of the most commonly predicted of these signals and the methods that are usually used for their detection. Unfortunately, there is no completely accurate method to identify any of these patterns, although increasingly complex computational techniques have been developed.

Keywords:

  • signal detection;
  • gene finding;
  • splicing;
  • transcription;
  • translation