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Gene structure prediction in plant genomes

Part 4. Bioinformatics

4.2. Gene Finding and Gene Structure

Short Specialist Review

  1. Volker Brendel

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g402303

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Brendel, V. 2005. Gene structure prediction in plant genomes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.2:21.

Author Information

  1. Iowa State University, Ames, IA, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

Following the completion of the Arabidopsis genome sequence, other plant genome sequences are rapidly accumulating. Computational gene structure annotation in these sequences is a pressing and challenging task. Current approaches are discussed, including ab initio methods, cDNA/EST spliced alignment, and protein spliced alignment. Best results are achieved with combined methods, and human expert annotation will remain necessary to achieve high reliability in large-scale annotation efforts.

Keywords:

  • gene prediction;
  • spliced alignment;
  • EST;
  • ab initio methods;
  • splice site prediction