Standard Article

Operon finding in bacteria

Part 4. Bioinformatics

4.2. Gene Finding and Gene Structure

Short Specialist Review

  1. Maria D. Ermolaeva

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g402306

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Ermolaeva, M. D. 2005. Operon finding in bacteria. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.2:20.

Author Information

  1. The Institute for Genomic Research, Rockville, MD, USA

Publication History

  1. Published Online: 15 JAN 2005

Abstract

A number of different strategies can be used to find operons and transcriptional units in bacterial and archaeal genomes. Some of these methods are purely computational: they rely only on the whole-genome sequence and gene predictions and do not require additional experimental data. Two such methods are discussed in this article: one relies on the fact that the distances between genes are shorter within transcriptional units than between them, while the second one takes advantage of the observation that operons tend to be conserved between genomes. Before discussing these operon-finding algorithms, we first present a purely computational approach for estimating the number of transcriptional units in the genome.

Keywords:

  • bacteria;
  • gene;
  • transcriptional unit;
  • operon;
  • regulation