Operon finding in bacteria
Part 4. Bioinformatics
4.2. Gene Finding and Gene Structure
Short Specialist Review
Published Online: 15 JAN 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Ermolaeva, M. D. 2005. Operon finding in bacteria. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.2:20.
- Published Online: 15 JAN 2005
A number of different strategies can be used to find operons and transcriptional units in bacterial and archaeal genomes. Some of these methods are purely computational: they rely only on the whole-genome sequence and gene predictions and do not require additional experimental data. Two such methods are discussed in this article: one relies on the fact that the distances between genes are shorter within transcriptional units than between them, while the second one takes advantage of the observation that operons tend to be conserved between genomes. Before discussing these operon-finding algorithms, we first present a purely computational approach for estimating the number of transcriptional units in the genome.
- transcriptional unit;