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Eukaryotic regulatory sequences

Part 4. Bioinformatics

4.2. Gene Finding and Gene Structure

Short Specialist Review

  1. Mathias Krull1,
  2. Edgar Wingender1,2

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g402310

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Krull, M. and Wingender, E. 2005. Eukaryotic regulatory sequences. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.2:22.

Author Information

  1. 1

    BIOBASE GmbH, Wolfenbüttel, Germany

  2. 2

    University of Göttingen, Göttingen, Germany

Publication History

  1. Published Online: 15 APR 2005

Abstract

The existence and clustering of particular regulatory sequences is the main determinant of specific gene expression. While the sequences of whole genomes for several species are now available, information on those control elements is relatively sparse. The numerousness of elements in the genome limits experimental identification. In-depth knowledge on DNA binding sites of transcription factors and their role in regulatory modules will enable genome-wide in silico site prediction with high sensitivity and specificity. Here we present a short review of the types of regulatory sequences and the computational methods that are applied for their characterization and prediction.

Keywords:

  • transcriptional regulation;
  • promoter;
  • enhancer;
  • locus control region;
  • DNA binding site;
  • transcription factor;
  • positional weight matrix;
  • composite element;
  • cis-element cluster;
  • in silico prediction