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Protein repeats

Part 4. Bioinformatics

4.3. Protein Function and Annotation

Short Specialist Review

  1. Carolina Perez-Iratxeta,
  2. Miguel A. Andrade

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g403301

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Perez-Iratxeta, C. and Andrade, M. A. 2005. Protein repeats. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.3:33.

Author Information

  1. Ottawa Health Research Institute, Ottawa, ON, Canada

Publication History

  1. Published Online: 15 JAN 2005

Abstract

More than 10% of all protein sequences contain a protein domain composed of units of similar structure, often of similar sequence, therefore arising by a process of duplication from an ancestral gene fragment. Structural and evolutionary constraints limit the length and structure of these repeats to a small number of categories. These domains composed of repeats are used mainly for protein binding and are more frequent in metazoan organisms than elsewhere. Low constraints in sequence allow high rates of sequence divergence between repeats, making their detection by sequence similarity difficult.

Keywords:

  • protein structure;
  • protein function;
  • protein evolution;
  • protein sequence similarity;
  • protein–protein interactions