Part 4. Bioinformatics
4.3. Protein Function and Annotation
Short Specialist Review
Published Online: 15 JAN 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Perez-Iratxeta, C. and Andrade, M. A. 2005. Protein repeats. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.3:33.
- Published Online: 15 JAN 2005
More than 10% of all protein sequences contain a protein domain composed of units of similar structure, often of similar sequence, therefore arising by a process of duplication from an ancestral gene fragment. Structural and evolutionary constraints limit the length and structure of these repeats to a small number of categories. These domains composed of repeats are used mainly for protein binding and are more frequent in metazoan organisms than elsewhere. Low constraints in sequence allow high rates of sequence divergence between repeats, making their detection by sequence similarity difficult.
- protein structure;
- protein function;
- protein evolution;
- protein sequence similarity;
- protein–protein interactions