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Phylogenomics for studies of microbial evolution

Part 4. Bioinformatics

4.4. Comparative Analysis and Phylogeny

Short Specialist Review

  1. Siv G. E. Andersson,
  2. Hans-Henrik Fuxelius

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g404301

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Andersson, S. G. E. and Fuxelius, H.-H. 2005. Phylogenomics for studies of microbial evolution. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.4:45.

Author Information

  1. Uppsala University, Uppsala, Sweden

Publication History

  1. Published Online: 15 NOV 2005

Abstract

The classification of microorganisms represents a major challenge, the basis of which has been an issue of debate for the past 100 years. Phylogenetic inference based on rRNA sequences is currently the gold standard for studies related to microbial evolution and classification. As more and more microbial genomes are added to the rapidly expanding pool of sequence data, automatic systems are being developed to meet the growing demand for large-scale phylogenetic analyses. However, the development of such tools and their application to biological problems has raised more questions than have been solved, and the debate about the extent to which microorganisms are related by vertical descent versus horizontal transmission is more heated than ever before. Here, we describe the recent development of methods and tools for phylogenomic studies and their application in microbiological research.

Keywords:

  • phylogenetic;
  • phylogenomics;
  • rRNA tree;
  • horizontal gene transfer;
  • microbial evolution