Mapping mutations on phylogenies
Part 4. Bioinformatics
4.4. Comparative Analysis and Phylogeny
Short Specialist Review
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Nielsen, R. 2005. Mapping mutations on phylogenies. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.4:46.
- Published Online: 15 APR 2005
This chapter provides a short review of recent methodologies developed for mapping mutations on phylogenies. Mapping of mutations, or character changes in general, using the maximum parsimony principle has been one of the most powerful tools in phylogenetics, and it has been used in a variety of different applications, for example, in the detection of correlated evolution and to identify selection acting on DNA sequences. However, many uses of parsimony mappings have been criticized because they focus on only one of many possible mappings and/or because they do not incorporate statistical uncertainty in the mapping. Recently developed probabilistic methods can incorporate statistical uncertainty in the character mappings. In these methods, focus is on a probability distribution of mutational mappings instead of a single estimate of the mutational mapping.
- Bayesian analysis;
- mapping mutations;