Standard Article

Connecting genes by comparative genomics

Part 4. Bioinformatics

4.4. Comparative Analysis and Phylogeny

Short Specialist Review

  1. Itai Yanai

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g404314

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Yanai, I. 2005. Connecting genes by comparative genomics. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.4:48.

Author Information

  1. Weizmann Institute of Science, Rehovot, Israel

Publication History

  1. Published Online: 15 NOV 2005

Abstract

Comparative genomics provides at least three methods beyond traditional sequence similarity for identifying functional links between genes: the examination of common phylogenetic distributions, the analysis of conserved proximity along the chromosomes of multiple genomes, and observations of fusions of genes into a multidomain gene in another organism.

Keywords:

  • comparative genomics;
  • orthology;
  • evolution;
  • phylogenetic profiling;
  • chromosomal proximity;
  • domain fusion