Low-level analysis of oligonucleotide expression arrays
Part 4. Bioinformatics
4.5. Computational Methods for High-throughput Genetic Analysis: Expression Profiling
Short Specialist Review
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Fang, X., Li, C. and Wong, W. H. 2005. Low-level analysis of oligonucleotide expression arrays. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.5:57.
- Published Online: 15 NOV 2005
High-density oligonucleotide microarray technology has been widely used in many biomedical research areas (Lockhart et al., 1996; Lipshutz et al., 1999). This section gives a brief introduction of oligonucleotide expression microarrays and low-level microarray data analysis, including feature extraction, normalization, and expression index calculation.
- high-density oligonucleotide microarray;
- feature extraction;
- presence call;
- background adjustment;
- expression index;