Analysis and prediction of membrane protein structure
Part 4. Bioinformatics
4.6. Methods for Structure Analysis and Prediction
Published Online: 15 OCT 2004
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Eyre, T. A., Partridge, L. and Thornton, J. M. 2004. Analysis and prediction of membrane protein structure. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.6:65.
- Published Online: 15 OCT 2004
Despite the importance of membrane proteins, relatively little is known even now about their structures because of the practical difficulties associated with the crystallization of these proteins. While we can identify transmembrane helices and predict their topology with high accuracy, we do not fully understand the forces that drive the packing of these helices in 3D. Recently, however, more membrane protein structures have become available and several computational studies have analyzed them. This chapter describes the results of these analyses and their implications for the prediction of 3D structural models for membrane proteins.
- transmembrane helix;
- membrane protein;
- structure analysis;
- structure prediction