Protein structure analysis and prediction
Part 4. Bioinformatics
4.6. Methods for Structure Analysis and Prediction
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Taylor, W. R. 2005. Protein structure analysis and prediction. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.6:64.
- Published Online: 15 NOV 2005
The comparative analysis of protein sequence and structure has provided great insights into the function and evolution of proteins. This approach relies on both sequence comparison and structure comparison with the latter, giving the deepest view on distant relationships, especially when just the overall fold of the proteins is compared. The establishment of correlation between sequence features and structural features can allow structure to be predicted from sequence. This can range from isolated fragments of structure (sometimes called motifs) to the overall fold of the proteins. With the progress in the determination of genomes and many new structures from structural genomics programs, there is an increasing wealth of data for comparative analysis.
- protein structure modeling;