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Protein structure analysis and prediction

Part 4. Bioinformatics

4.6. Methods for Structure Analysis and Prediction

Introductory Review

  1. William R. Taylor

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g406119

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Taylor, W. R. 2005. Protein structure analysis and prediction. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.6:64.

Author Information

  1. National Institute for Medical Research, London, UK

Publication History

  1. Published Online: 15 NOV 2005

Abstract

The comparative analysis of protein sequence and structure has provided great insights into the function and evolution of proteins. This approach relies on both sequence comparison and structure comparison with the latter, giving the deepest view on distant relationships, especially when just the overall fold of the proteins is compared. The establishment of correlation between sequence features and structural features can allow structure to be predicted from sequence. This can range from isolated fragments of structure (sometimes called motifs) to the overall fold of the proteins. With the progress in the determination of genomes and many new structures from structural genomics programs, there is an increasing wealth of data for comparative analysis.

Keywords:

  • protein structure modeling;
  • comparison;
  • prediction;
  • motifs