Ab initio structure prediction
Part 4. Bioinformatics
4.6. Methods for Structure Analysis and Prediction
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Baker, D. and Taylor, W. R. 2005. Ab initio structure prediction. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 NOV 2005
The prediction of a folded protein structure from just its amino acid sequence (ab initio prediction) has been an outstanding problem in theoretical molecular biology for many years. Attempts based purely on physicochemical principles have had little success (except for short peptides), and a variety of approaches have been developed on the basis of the incorporation of known protein features to overcome this limitation. The most successful of these are based on building proteins from short fragments, and the performance of the ROSETTA program, which uses this method, is described.
- protein structure prediction;
- Rosetta method